Nearly 100,000 people gathered on the Boston Common and marched to City Hall on April 5 in protest of President Donald Trump’s administration.

The “Hands Off Boston” demonstration was one of more than 1,500 held across the country. Protestors held signs supporting immigration, transgender rights, and scientific research. Other signs displayed messages opposing cuts to government programs, such as Medicaid, social security, international aid and education, led by billionaire Elon Musk’s Department of Government Efficiency.

Sen. Ed Markey led protestors down Tremont Street toward City Hall before addressing the crowd. It took nearly two hours for the last of the attendees to reach the end of the route. Other speakers included Lt. Gov. Kim Driscoll, Rep. Ayanna Pressley, Mayor Michelle Wu, three union presidents and four nonprofit leaders.

The event was emceed by Rev. Mariama White-Hammond, founder of the New Roots AME Church in Dorchester, and Reggi Alkiewicz, civic engagement coordinator at the North American Indian Center of Boston.

“We are here today to tell Donald Trump and Elon Musk, hands off our rights. Hands off our healthcare. Hands off our jobs, our social security,” Markey said.

Pressley compared the nationwide protest to the Civil Rights Movement of the 1960s. “You are a beautiful sight to behold, and you affirm that the power of the people has always been greater than the people in power,” she said. “This is our chapter of the civil rights movement, which we are still very much in.”

She also criticized the administration’s attacks on diversity, equity, and inclusion efforts. “The reason they’re anti-woke is because they want you to stay asleep. They want you to be ignorant. They want you to be indifferent. They want you to be inactive,” Pressley said.

Driscoll, who spoke at the Boston Common before the march, emphasized Massachusetts’ history of protest. “You come for one of us, you come for all of us, and nobody knows that better than right here in the Commonwealth of Massachusetts,” she said.

Wu leaned on her background as the daughter of immigrants. “I’m here today standing on the shoulders of my mom and dad, and so many who came before. And alongside our elders, this is about our kids,” she said. “This is about the world we want them to grow up in. I refuse to accept that my kids and all our kids could grow up in a world where threats and intimidation are the tactics that the president uses to get his way.”

“I refuse to accept that they could grow up in a world where immigrants like their grandma and grandpa are automatically presumed to be criminals,” Wu said.

Many speakers referred to Rumeysa Öztürk, an international student at Tufts University who was arrested March 25 by plain-clothes immigration officials in Somerville, despite being in the country legally. The protest came in the midst of a nationwide wave of student visa revocations. UMass Boston Chancellor Marcelo Suárez-Orozco announced that seven visas had been revoked at the university just hours after the event, later updating the count to 11 during a campus update meeting Wednesday.

Organizers said approximately 100,000 people filled City Hall Plaza and the surrounding streets. No arrests were made in connection with the protest, according to the Boston Police Department. One protester, who said he has attended approximately 20 protests at the Boston Common since the 1970s and spoke on the condition of anonymity out of fear for his safety, said it was the largest he had seen.

One protester said she was carrying the same sign she made for the nationwide Women’s March in January 2017, which took place one day after Trump’s first inauguration. White-Hammond, one of the emcees on April 5, also spoke at the 2017 event. According to the Associated Press, approximately 100,000 people in Boston attended the 2017 march.

Another protester, dressed as a Revolutionary War soldier, held a sign that read, “George Washington Told Congress No Kings.”

Others dressed in red cloaks, as seen in “The Handmaid’s Tale,” the dystopian television show. One stood on stage for most of the event holding a sign that read, “I rise with the intent of getting into good trouble,” quoting New Jersey Sen. Cory Booker at the beginning of his record-breaking speech on the floor of the U.S. Senate.